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Optical Devices and Molecular Imaging for Cervical Neoplasia

Project Publications
Click below to return to the project mainpage.
Click below to return to the project mainpage.
Click below for publications from 2007 to the present.
Publications:
From 2006 and before
  • Yamal JM, Cox D, Hittelman WN, Boiko I, Malpica A, Guillaud M, MacAulay C, Follen M, Vlastos AT. Quantitative histopathology and chromosome 9 polysomy in a clinical trial of 4-HPR. Gynecol Oncol 2004;94:296-306.  (pdf)

  • Sokolov K, Aaron J, Kumar S, Mack V, Collier T, Coghlan L, Gillenwater A, Adler Storthz K, Follen M, Richards Kortum R. Molecular imaging of carcinogenesis with immuno-targeted nanoparticles. Conf Proc IEEE Eng Med Biol Soc 2004;7:5292-5.  (pdf)

  • Shinn E, Basen-Engquist K, Le T, Hansis-Diarte A, Bostic D, Martinez-Cross J, Santos A, Follen M. Distress after an abnormal Pap smear result: scale development and psychometric validation. Prev Med 2004;39:404-12.  (pdf)

  • Rivoire K, Nath A, Cox D, Atkinson EN, Richards-Kortum R, Follen M. The effects of repeated spectroscopic pressure measurements on fluorescence intensity in the cervix. Am J Obstet Gynecol 2004;191:1606-17.  (pdf)

  • Nath A, Rivoire K, Chang S, West L, Cantor SB, Basen-Engquist K, Adler-Storthz K, Cox DD, Atkinson EN, Staerkel G, MacAulay C, Richards-Kortum R, Follen M. A pilot study for a screening trial of cervical fluorescence spectroscopy. Int J Gynecol Cancer 2004;14:1097-107.  (pdf)

  • Nath A, Rivoire K, Chang S, Cox D, Atkinson EN, Follen M, Richards-Kortum R. Effect of probe pressure on cervical fluorescence spectroscopy measurements. J Biomed Opt 2004;9:523-33.  (pdf)

  • Lee BN, Follen M, Shen DY, Malpica A, Adler-Storthz K, Shearer WT, Reuben JM. Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions. Clin Diagn Lab Immunol 2004;11:239-44.  (pdf)

  • Guillaud M, Cox D, Malpica A, Staerkel G, Matisic J, Van Niekirk D, Adler-Storthz K, Poulin N, Follen M, MacAulay C. Quantitative histopathological analysis of cervical intra-epithelial neoplasia sections: methodological issues. Cell Oncol 2004;26:31-43.  (pdf)

  • Guillaud M, Cox D, Adler-Storthz K, Malpica A, Staerkel G, Matisic J, Van Niekerk D, Poulin N, Follen M, MacAulay C. Exploratory analysis of quantitative histopathology of cervical intraepithelial neoplasia: objectivity, reproducibility, malignancy-associated changes, and human papillomavirus. Cytometry A 2004;60:81-9.  (pdf)

  • Chiu D, Guillaud M, Cox D, Follen M, MacAulay C. Quality assurance system using statistical process control: an implementation for image cytometry. Cell Oncol 2004;26:101-17.  (pdf)

  • Chang SK, Arifler D, Drezek R, Follen M, Richards-Kortum R. Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements. J Biomed Opt 2004;9:511-22.  (pdf)
Click below for publications from 2007 to the present.
  • Zou C, Vlastos AT, Yang L, Wang J, Brewer M, Follen M. Effect of 4-hydroxyphenylretinamide on human cervical epithelial and cancer cell lines. J Soc Gynecol Investig 2003;10:41-8.  (pdf)

  • Wu X, Tortolero-Luna G, Zhao H, Phatak D, Spitz MR, Follen M. Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix. Clin Cancer Res 2003;9:3356-61.  (pdf)

  • Vlastos AT, Schottenfeld D, Follen M. Biomarkers and their use in cervical cancer chemoprevention. Crit Rev Oncol Hematol 2003;46:261-73.  (pdf)

  • Vlastos AT, Malpica A, Follen M. Lymphangioma circumscriptum of the vulva: a review of the literature. Obstet Gynecol 2003;101:946-54.  (pdf)

  • Swartz R, West L, Boiko I, Malpica A, MacAulay C, Carraro A, Guillaud M, Cox D, Follen M. Use of nuclear morphometry characteristics to distinguish between normal and abnormal cervical glandular histologies. Anal Cell Pathol 2003;25:193-200.  (pdf)

  • Sung KB, Richards-Kortum R, Follen M, Malpica A, Liang C, Descour M. Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo. Opt Express 2003;11:3171-81.  (pdf)

  • Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res 2003;63:1999-2004.  (pdf)

  • Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat 2003;2:491-504.  (link)

  • Pavlova I, Sokolov K, Drezek R, Malpica A, Follen M, Richards-Kortum R. Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy. Photochem Photobiol 2003;77:550-5.  (pdf)

  • Huh JJ, Wolf JK, Fightmaster DL, Lotan R, Follen M. Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells. Gynecol Oncol 2003;89:243-50.  (pdf)

  • Gill EM, Malpica A, Alford RE, Nath AR, Follen M, Richards-Kortum RR, Ramanujam N. Relationship between collagen autofluorescence of the human cervix and menopausal status. Photochem Photobiol 2003;77:653-8.  (pdf)

  • Follen M, Meyskens FL, Jr., Alvarez RD, Walker JL, Bell MC, Storthz KA, Sastry J, Roy K, Richards-Kortum R, Cornelison TL. Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers. Cancer 2003;98:2044-51.  (pdf)

  • Follen M, Levenback CF, Iyer RB, Grigsby PW, Boss EA, Delpassand ES, Fornage BD, Fishman EK. Imaging in cervical cancer. Cancer 2003;98:2028-38.  (pdf)

  • Drezek RA, Richards-Kortum R, Brewer MA, Feld MS, Pitris C, Ferenczy A, Faupel ML, Follen M. Optical imaging of the cervix. Cancer 2003;98:2015-27.  (pdf)

  • Drezek R, Guillaud M, Collier T, Boiko I, Malpica A, Macaulay C, Follen M, Richards-Kortum R. Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture. J Biomed Opt 2003;8:7-16.  (pdf)

  • Cox DD, Chang SK, Dawood MY, Staerkel G, Utzinger U, Richards-Kortum RR, Follen M. Detecting the signal of the menstrual cycle in fluorescence spectroscopy of the cervix. Appl Spectrosc 2003;57:67-72.  (pdf)

  • Cantor SB, Fahs MC, Mandelblatt JS, Myers ER, Sanders GD. Decision science and cervical cancer. Cancer 2003; 98:2003-8.  (pdf)

  • Brookner C, Utzinger U, Follen M, Richards-Kortum R, Cox D, Atkinson EN. Effects of biographical variables on cervical fluorescence emission spectra. J Biomed Opt 2003;8:479-83.  (pdf)

  • Brewer MA, Johnson K, Follen M, Gershenson D, Bast R, Jr. Prevention of ovarian cancer: intraepithelial neoplasia. Clin Cancer Res 2003;9:20-30.  (pdf)

  • Benavides J, Chang S, Park S, Richards-Kortum R, Mackinnon N, Macaulay C, Milbourne A, Malpica A, Follen M. Multispectral digital colposcopy for in vivo detection of cervical cancer. Opt Express 2003;11:1223-36.  (pdf)

  • Basen-Engquist K, Shinn EH, Warneke C, de Moor C, Le T, Richards-Kortum R, Follen M. Patient distress and satisfaction with optical spectroscopy in cervical dysplasia detection. Am J Obstet Gynecol 2003;189:1136-42.  (pdf)

  • Arifler D, Guillaud M, Carraro A, Malpica A, Follen M, Richards-Kortum R. Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition. J Biomed Opt 2003;8:484-94.  (pdf)

  • Zuluaga AF, Drezek R, Collier T, Lotan R, Follen M, Richards-Kortum R. Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension. J Biomed Opt 2002;7:398-403.  (pdf)

  • Zou C, Vlastos AT, Yang L, Wang J, Nishioka K, Follen M. Effects of difluoromethylornithine on growth inhibition and apoptosis in human cervical epithelial and cancerous cell lines. Gynecol Oncol 2002;85:266-73.  (pdf)

  • West LA, Swartz R, Cox D, Boiko IV, Malpica A, Macaulay C, Follen M. Cytometric features of cell nuclei of adenocarcinoma in situ and invasive adenocarcinoma of the cervix. Am J Obstet Gynecol 2002;187:1566-73.  (pdf)

  • Vlastos AT, Malpica A, Follen M. Lymphangioma circumscriptum of the vulva. Eur J Gynaecol Oncol 2002;23:86-7.

  • Vlastos AT, Levy LB, Malpica A, Follen M. Loop Electrosurgical Excision Procedure in Vulvar Intraepithelial Neoplasia Treatment. J Low Genit Tract Dis 2002;6:232-8.  (pdf)

  • Sung KB, Liang C, Descour M, Collier T, Follen M, Richards-Kortum R. Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues. IEEE Trans Biomed Eng 2002;49:1168-72.  (pdf)

  • Sung KB, Liang C, Descour M, Collier T, Follen M, Malpica A, Richards-Kortum R. Near real time in vivo fibre optic confocal microscopy: sub-cellular structure resolved. J Microsc 2002;207:137-45.  (pdf)

  • Sokolov K, Follen M, Richards-Kortum R. Optical spectroscopy for detection of neoplasia. Curr Opin Chem Biol 2002;6:651-8.  (pdf)

  • O'Shaughnessy JA, Kelloff GJ, Gordon GB, Dannenberg AJ, Hong WK, Fabian CJ, Sigman CC, Bertagnolli MM, Stratton SP, Lam S, Nelson WG, Meyskens FL, Alberts DS, Follen M, Rustgi AK, Papadimitrakopoulou V, Scardino PT, Gazdar AF, Wattenberg LW, Sporn MB, Sakr WA, Lippman SM, Von Hoff DD. Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development. Clin Cancer Res 2002;8:314-46.  (pdf)

  • Mirabal YN, Chang SK, Atkinson EN, Malpica A, Follen M, Richards-Kortum R. Reflectance spectroscopy for in vivo detection of cervical precancer. J Biomed Opt 2002;7:587-94.  (pdf)

  • MacAulay C, Richards-Kortum R, Utzinger U, Fedyk A, Atkinson E, Cox D, Follen M. Variation of fluorescence spectroscopy during the menstrual cycle. Opt Express 2002;10:493-504.  (pdf)

  • Follen M, Vlastos AT, Meyskens FL, Jr., Atkinson EN, Schottenfeld D. Why phase II trials in cervical chemoprevention are negative: what have we learned? Cancer Causes Control 2002;13:855-73.  (pdf)

  • Collier T, Lacy A, Richards-Kortum R, Malpica A, Follen M. Near real-time confocal microscopy of amelanotic tissue: detection of dysplasia in ex vivo cervical tissue. Acad Radiol 2002;9:504-12.  (pdf)

  • Clark A, Collier T, Lacy A, Follen M, Malpica A, Gillenwater A, Richards-Kortum R. Detection of dysplasia with near real time confocal microscopy. Biomed Sci Instrum 2002;38:393-8.

  • Chang SK, Follen M, Malpica A, Utzinger U, Staerkel G, Cox D, Atkinson EN, MacAulay C, Richards-Kortum R. Optimal excitation wavelengths for discrimination of cervical neoplasia. IEEE Trans Biomed Eng 2002;49:1102-11.  (pdf)

  • Chang SK, Dawood MY, Staerkel G, Utzinger U, Atkinson EN, Richards-Kortum RR, Follen M. Fluorescence spectroscopy for cervical precancer detection: Is there variance across the menstrual cycle? J Biomed Opt 2002;7:595-602.  (pdf)

  • Brewer M, Utzinger U, Li Y, Atkinson EN, Satterfield W, Auersperg N, Richards-Kortum R, Follen M, Bast R. Fluorescence spectroscopy as a biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents. J Biomed Opt 2002;7:20-6.  (pdf)
  • Utzinger U, Brewer M, Silva E, Gershenson D, Blast RC, Jr., Follen M, Richards-Kortum R. Reflectance spectroscopy for in vivo characterization of ovarian tissue. Lasers Surg Med 2001;28:56-66.  (pdf)

  • Ramanujam N, Richards-Kortum R, Thomsen S, Mahadevan-Jansen A, Follen M, Chance B. Low Temperature Fluorescence Imaging of Freeze-trapped Human Cervical Tissues. Opt Express 2001;8:335-43.  (pdf)

  • Hoque A, Lippman SM, Boiko IV, Atkinson EN, Sneige N, Sahin A, Weber DM, Risin S, Lagios MD, Schwarting R, Colburn WJ, Dhingra K, Follen M, Kelloff GJ, Boone CW, Hittelman WN. Quantitative nuclear morphometry by image analysis for prediction of recurrence of ductal carcinoma in situ of the breast. Cancer Epidemiol Biomarkers Prev 2001;10:249-59.  (pdf)

  • Herbst AL, Pickett KE, Follen M, Noller KL. The management of ASCUS cervical cytologic abnormalities and HPV testing: a cautionary note. Obstet Gynecol 2001;98:849-51.  (pdf)

  • Follen M, Schottenfeld D. Surrogate endpoint biomarkers and their modulation in cervical chemoprevention trials. Cancer 2001;91:1758-76.  (pdf)

  • Follen M, Meyskens FL, Jr., Atkinson EN, Schottenfeld D. Why most randomized phase II cervical cancer chemoprevention trials are uninformative: lessons for the future. J Natl Cancer Inst 2001;93:1293-6.  (pdf)

  • Follen M, Atkinson EN, Schottenfeld D, Malpica A, West L, Lippman S, Zou C, Hittelman WN, Lotan R, Hong WK. A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix. Clin Cancer Res 2001;7:3356-65.  (pdf)

  • Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M, Richards-Kortum R. Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications. J Biomed Opt 2001;6:385-96.  (pdf)

  • Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, Richards-Kortum R. Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia. Photochem Photobiol 2001;73:636-41.  (pdf)

  • Coghlan L, Utzinger U, Richards-Kortum R, Brookner C, Zuluaga A, Gimenez-Conti I, Follen M. Fluorescence spectroscopy of epithelial tissue throughout the dysplasia-carcinoma sequence in an animal model: spectroscopic changes precede morphologic changes. Lasers Surg Med 2001;29:1-10.  (pdf)

  • Brewer M, Utzinger U, Silva E, Gershenson D, Bast RC, Jr., Follen M, Richards-Kortum R. Fluorescence spectroscopy for in vivo characterization of ovarian tissue. Lasers Surg Med 2001;29:128-35.  (pdf)

  • Brewer M, Utzinger U, Satterfield W, Hill L, Gershenson D, Bast R, Wharton JT, Richards-Kortum R, Follen M. Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention. Cancer Epidemiol Biomarkers Prev 2001;10:889-93.  (pdf)

  • Brewer M, Baze W, Hill L, Utzinger U, Wharton JT, Follen M, Khan-Dawood F, Satterfield W. Rhesus macaque model for ovarian cancer chemoprevention. Comp Med 2001;51:424-9.
  • Morris RT, Gershenson DM, Silva EG, Follen M, Morris M, Wharton JT. Outcome and reproductive function after conservative surgery for borderline ovarian tumors. Obstet Gynecol 2000;95:541-7.  (pdf)

  • Gordinier ME, Ramondetta LM, Parker LP, Wolf JK, Follen M, Gershenson DM, Bodurka-Bevers D. Survey of female gynecologic oncologists and fellows: balancing professional and personal life. Gynecol Oncol 2000;79:309-14.  (pdf)

  • Follen M, Richards-Kortum R. Emerging technologies and cervical cancer. J Natl Cancer Inst 2000;92:363-5.  (pdf)

  • Drezek RA, Collier T, Brookner CK, Malpica A, Lotan R, Richards-Kortum RR, Follen M. Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid. Am J Obstet Gynecol 2000;182:1135-9.  (pdf)

  • Collier T, Shen P, de Pradier B, Sung KB, Richards-Kortum R, Follen M, Malpica A. Near real time confocal microscopy of amelanotic tissue: dynamics of aceto-whitening enable nuclear segmentation. Opt Express 2000;6:40-8.  (pdf)

  • Coghlan L, Utzinger U, Drezek R, Heintzelmann D, Zuluaga A, Brookner C, Richards-Kortum R, Gimenez-Conti I, Follen M. Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model. Opt Express 2000;7:436-46.  (pdf)

  • Cantor SB, Kattan MW.  Determining the area under the ROC curve for a binary diagnostic test.  Med Decis Making 2000;20:468-470. (pdf)

  • Brookner CK, Follen M, Boiko I, Galvan J, Thomsen S, Malpica A, Suzuki S, Lotan R, Richards-Kortum R. Autofluorescence patterns in short-term cultures of normal cervical tissue. Photochem Photobiol 2000;71:730-6.  (pdf)
  • Xu XC, Mitchell MF, Silva E, Jetten A, Lotan R. Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin, and cornifin in cervical intraepithelial neoplasia. Clin Cancer Res 1999;5:1503-8.  (pdf)

  • Utzinger U, Trujillo EV, Atkinson EN, Mitchell MF, Cantor SB, Richards-Kortum R. Performance estimation of diagnostic tests for cervical precancer based on fluorescence spectroscopy: effects of tissue type, sample size, population, and signal-to-noise ratio. IEEE Trans Biomed Eng 1999;46:1293-303.  (pdf)

  • Swan DC, Tucker RA, Tortolero-Luna G, Mitchell MF, Wideroff L, Unger ER, Nisenbaum RA, Reeves WC, Icenogle JP. Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type. J Clin Microbiol 1999;37:1030-4.  (pdf)

  • Sokolov K, Drezek R, Gossage K, Richards-Kortum R. Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology. Opt Express 1999;5:302-17.  (pdf)

  • Sarkar AK, Mitchell MF, Hamada K, Buchl SJ, Satterfield WC, Schapiro SJ, Keeling ME, Sastry KJ. Evaluation of cellular immune responses in rhesus monkeys subjected to adenovirus-mediated gene transfer into the cervix. Cancer Gene Ther 1999;6:220-7.  (pdf)

  • Poulin N, Boiko I, MacAulay C, Boone C, Nishioka K, Hittelman W, Mitchell MF. Nuclear morphometry as an intermediate endpoint biomarker in chemoprevention of cervical carcinoma using alpha-difluoromethylornithine. Cytometry 1999;38:214-23.  (pdf)

  • Mitchell MF, Cantor SB, Ramanujam N, Tortolero-Luna G, Richards-Kortum R. Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix. Obstet Gynecol 1999;93:462-70.  (pdf)

  • Mitchell MF, Cantor SB, Brookner C, Utzinger U, Schottenfeld D, Richards-Kortum R. Screening for squamous intraepithelial lesions with fluorescence spectroscopy. Obstet Gynecol 1999;94:889-96.  (pdf)

  • Lee BN, Follen M, Tortolero-Luna G, Eriksen N, Helfgott A, Hammill H, Shearer WT, Reuben JM. Synthesis of IFN-gamma by CD8(+) T cells is preserved in HIV-infected women with HPV-related cervical squamous intraepithelial lesions. Gynecol Oncol 1999;75:379-86.  (pdf)

  • Ke LD, Adler-Storthz K, Mitchell MF, Clayman GL, Chen Z. Expression of human papillomavirus E7 mRNA in human oral and cervical neoplasia and cell lines. Oral Oncol 1999;35:415-20.  (pdf)

  • Cantor SB, Sun CC, Tortolero-Luna G, Richards-Kortum R, Follen M. A comparison of C/B ratios from studies using receiver operating characteristic curve analysis. J Clin Epidemiol 1999;52:885-92.  (pdf)

  • Brookner CK, Utzinger U, Staerkel G, Richards-Kortum R, Mitchell MF. Cervical fluorescence of normal women. Lasers Surg Med 1999;24:29-37.  (pdf)

  • Brewer MA, Mitchell MF, Bast RC. Prevention of ovarian cancer. In Vivo 1999;13:99-106.

  • Brewer M, Gershenson DM, Herzog CE, Mitchell MF, Silva EG, Wharton JT. Outcome and reproductive function after chemotherapy for ovarian dysgerminoma. J Clin Oncol 1999;17:2670-75.  (pdf)

  • Bacus JW, Boone CW, Bacus JV, Follen M, Kelloff GJ, Kagan V, Lippman SM. Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials. Cancer Epidemiol Biomarkers Prev 1999;8:1087-94.  (pdf)

  • Agrawal A, Utzinger U, Brookner C, Pitris C, Mitchell MF, Richards-Kortum R. Fluorescence spectroscopy of the cervix: influence of acetic acid, cervical mucus, and vaginal medications. Lasers Surg Med 1999;25:237-49.  (pdf)
  • Tortolero-Luna G, Mitchell MF, Swan DC, Tucker RA, Wideroff L, Icenogle JP. A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups. Cad Saude Publica 1998;14 Suppl 3:149-59.

  • Mitchell MF, Tortolero-Luna G, Lee JJ, Hittelman WN, Lotan R, Wharton JT, Hong WK, Nishioka K. Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia. Clin Cancer Res 1998;4:303-10.  (pdf)

  • Mitchell MF, Tortolero-Luna G, Cook E, Whittaker L, Rhodes-Morris H, Silva E. A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intraepithelial lesions of the cervix. Obstet Gynecol 1998;92:737-44.  (pdf)

  • Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, Richards-Kortum R. Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol 1998;91:626-31.  (pdf)

  • Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Utzinger U, Richards-Kortum R. Development of a fiber optic probe to measure NIR Raman spectra of cervical tissue in vivo. Photochem Photobiol 1998;68:427-31.  (pdf)

  • Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Malpica A, Thomsen S, Utzinger U, Richards-Kortum R. Near-infrared Raman spectroscopy for in vitro detection of cervical precancers. Photochem Photobiol 1998;68:123-32.  (pdf)

  • Cantor SB, Mitchell MF, Tortolero-Luna G, Bratka CS, Bodurka DC, Richards-Kortum R. Cost-effectiveness analysis of diagnosis and management of cervical squamous intraepithelial lesions. Obstet Gynecol 1998;91:270-7.  (pdf)

  • Boiko IV, Mitchell MF, Hu W, Pandey DK, Mathevet P, Malpica A, Hittelman WN. Epidermal growth factor receptor expression in cervical intraepithelial neoplasia and its modulation during an alpha-difluoromethylornithine chemoprevention trial. Clin Cancer Res 1998;4:1383-91.  (pdf)
  • Oridate N, Suzuki S, Higuchi M, Mitchell MF, Hong WK, Lotan R. Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J Natl Cancer Inst 1997;89:1191-8.  (pdf)

  • Mitchell MF, Tortolero-Luna G, Lee JJ, Hittelman WK, Lotan R, Wharton JT, Hong WK, Nishioka K. Polyamine measurements in the uterine cervix. J Cell Biochem Suppl 1997;28-29:125-32.  (pdf)

  • Hu W, Mitchell MF, Boiko IV, Linares A, Kim HG, Malpica A, Tortolero-Luna G, Hittelman WN. Progressive dysregulation of proliferation during cervical carcinogenesis as measured by MPM-2 antibody staining. Cancer Epidemiol Biomarkers Prev 1997;6:711-8.  (pdf)

  • Fujiwara H, Tortolero-Luna G, Mitchell MF, Koulos JP, Wright TC, Jr. Adenocarcinoma of the cervix. Expression and clinical significance of estrogen and progesterone receptors. Cancer 1997;79:505-12.  (pdf)

  • Brookner CK, Agrawal A, Trujillo EV, Mitchell MF, Richards-Kortum RR. Safety analysis: relative risks of ultraviolet exposure from fluorescence spectroscopy and colposcopy are comparable. Photochem Photobiol 1997;65:1020-5.  (pdf)

  • Boiko IV, Mitchell MF, Pandey DK, White RA, Hu W, Malpica A, Nishioka K, Boone CW, Atkinson EN, Hittelman WN. DNA image cytometric measurement as a surrogate end point biomarker in a phase I trial of alpha-difluoromethylornithine for cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev 1997;6:849-55.  (pdf)
  • Wolf JK, Levenback C, Malpica A, Morris M, Burke T, Mitchell MF. Adenocarcinoma in situ of the cervix: significance of cone biopsy margins. Obstet Gynecol 1996;88:82-6.  (pdf)

  • Richards-Kortum R, Sevick-Muraca E. Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem 1996;47:555-606.  (pdf)

  • Ratliff CR, Gershenson DM, Morris M, Burke TW, Levenback C, Schover LR, Mitchell MF, Atkinson EN, Wharton JT. Sexual adjustment of patients undergoing gracilis myocutaneous flap vaginal reconstruction in conjunction with pelvic exenteration. Cancer 1996;78:2229-35.  (pdf)

  • Ramanujam N, Mitchell MF, Mahadevan-Jansen A, Thomsen SL, Staerkel G, Malpica A, Wright T, Atkinson N, Richards-Kortum R. Cervical precancer detection using a multivariate statistical algorithm based on laser-induced fluorescence spectra at multiple excitation wavelengths. Photochem Photobiol 1996;64:720-35.  (pdf)

  • Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, Richards-Kortum R. Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo. Lasers Surg Med 1996;19:46-62.  (pdf)

  • Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson N, Richards-Kortum R. Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser-induced fluorescence spectra at multiple excitation wavelengths. Lasers Surg Med 1996;19:63-74.  (pdf)

  • Mitchell MF, Tortolero-Luna G, Wright T, Sarkar A, Richards-Kortum R, Hong WK, Schottenfeld D. Cervical human papillomavirus infection and intraepithelial neoplasia: a review. J Natl Cancer Inst Monogr 1996:17-25.

  • Mitchell MF, Hamada K, Sastry KJ, Sarkar A, Tortolero-Luna G, Wharton JT, Roth JA. Transgene expression in the rhesus cervix mediated by an adenovirus expressing beta-galactosidase. Am J Obstet Gynecol 1996;174:1094-101.  (pdf)

  • Liu J, Wang Y, Gu P, Patrick J, Crist KA, Sabourin CL, Stoner GD, Mitchell MF, Fanning JD, Kim K, Goldblatt PJ, Kelloff GJ, Boone CW, You M. Detection of genomic alterations in human cervical cancer by two-dimensional gel electrophoresis. J Cell Biochem Suppl 1996;25:41-8.  (pdf)

  • Hamada K, Zhang WW, Alemany R, Wolf J, Roth JA, Mitchell MF. Growth inhibition of human cervical cancer cells with the recombinant adenovirus p53 in vitro. Gynecol Oncol 1996;60:373-9.  (pdf)

  • Hamada K, Sakaue M, Alemany R, Zhang WW, Horio Y, Roth JA, Mitchell MF. Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol Oncol 1996;63:219-27.  (pdf)

  • Hamada K, Alemany R, Zhang WW, Hittelman WN, Lotan R, Roth JA, Mitchell MF. Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer. Cancer Res 1996;56:3047-54.  (pdf)
  • Tortolero-Luna G, Mitchell MF. The epidemiology of ovarian cancer. J Cell Biochem Suppl 1995;23:200-7.

  • Silva EG, Tornos C, Malpica A, Mitchell MF. Uterine neoplasms in patients treated with tamoxifen. J Cell Biochem Suppl 1995;23:179-83.

  • Sarkar AK, Tortolero-Luna G, Nehete PN, Arlinghaus RB, Mitchell MF, Sastry KJ. Studies on in vivo induction of cytotoxic T lymphocyte responses by synthetic peptides from E6 and E7 oncoproteins of human papillomavirus type 16. Viral Immunol 1995;8:165-74.

  • Oridate N, Lotan D, Mitchell MF, Hong WK, Lotan R. Inhibition of proliferation and induction of apoptosis in cervical carcinoma cells by retinoids: implications for chemoprevention. J Cell Biochem Suppl 1995;23:80-6.

  • Nishioka K, Melgarejo AB, Lyon RR, Mitchell MF. Polyamines as biomarkers of cervical intraepithelial neoplasia. J Cell Biochem Suppl 1995;23:87-95.

  • Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK. Chemoprevention trials in the cervix: design, feasibility, and recruitment. J Cell Biochem Suppl 1995;23:104-12.

  • Mitchell MF, Hittelman WK, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Wharton JT, Hong WK. Chemoprevention trials and surrogate end point biomarkers in the cervix. Cancer 1995;76:1956-77.  (pdf)

  • McCabe K, Nahn PA, Sahin AA, Mitchell MF. Enterobiasis of the ovary in a patient with cervical carcinoma in situ. Infect Dis Obstet Gynecol 1995;2:231-4.  (pdf)

  • Marino BD, Burke TW, Tornos C, Chuang L, Mitchell MF, Tortolero-Luna G, Morris M, Gershenson DM. Staging laparotomy for endometrial carcinoma: assessment of peritoneal spread. Gynecol Oncol 1995;56:34-8.  (pdf)

  • Fujiwara H, Mitchell MF, Arseneau J, Hale RJ, Wright TC, Jr. Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. Cancer 1995;76:1591-600.  (pdf)

  • Chuang L, Burke TW, Tornos C, Marino BD, Mitchell MF, Tortolero-Luna G, Levenback C, Morris M, Gershenson DM. Staging laparotomy for endometrial carcinoma: assessment of retroperitoneal lymph nodes. Gynecol Oncol 1995;58:189-93.  (pdf)

  • Atkinson EN, Mitchell MF, Ramanujam N, Richards-Kortum R. Statistical techniques for diagnosing CIN using fluorescence spectroscopy: SVD and CART. J Cell Biochem Suppl 1995;23:125-30.
  • Tortolero-Luna G, Mitchell MF, Rhodes-Morris HE. Epidemiology and screening of ovarian cancer. Obstet Gynecol Clin North Am 1994;21:1-23.

  • Richards-Kortum R, Mitchell MF, Ramanujam N, Mahadevan A, Thomsen S. In vivo fluorescence spectroscopy: potential for non-invasive, automated diagnosis of cervical intraepithelial neoplasia and use as a surrogate endpoint biomarker. J Cell Biochem Suppl 1994;19:111-9.

  • Ramanujam N, Mitchell MF, Mahadevan A, Warren S, Thomsen S, Silva E, Richards-Kortum R. In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. Proc Natl Acad Sci U S A 1994;91:10193-7.  (pdf)

  • Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum R. Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN). Gynecol Oncol 1994;52:31-8.  (pdf)

  • Morris M, Gershenson DM, Burke TW, Mitchell MF, Levenback C, Atkinson N, Wharton JT. A phase II study of carboplatin and cisplatin in advanced or recurrent squamous carcinoma of the uterine cervix. Gynecol Oncol 1994;53:234-8.  (pdf)

  • Mitchell MF, Hittelman WN, Hong WK, Lotan R, Schottenfeld D. The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers. Cancer Epidemiol Biomarkers Prev 1994;3:619-26.  (pdf)
NIH regulations stipulate that peer-reviewed publcations based on NIH grant-funded research must be made publically available.  The complete versions of the article citations below can be downloaded directly from this site (to access a particular article, please click "pdf" after the citation).  For entries without pdf links, we are working to post these articles.

(In the event that any provided links do not work, please contact us at dcsc@bccrc.ca.)
  • Zuluaga AF, Follen M, Boiko I, Malpica A, Richards-Kortum R. Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue. Am J Obstet Gynecol 2005;193:83-8.  (pdf)

  • Vlastos AT, West LA, Atkinson EN, Boiko I, Malpica A, Hong WK, Follen M. Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3. Clin Cancer Res 2005;11:390-6.  (pdf)

  • Swartz RJ, West LA, Boiko I, Malpica A, Guillaud M, Macaulay C, Follen M, Atkinson EN, Cox DD. Classification using the cumulative log-odds in the quantitative pathologic diagnosis of adenocarcinoma of the cervix. Gynecol Oncol 2005;99:S24-31.  (pdf)

  • Swan DC, Rajeevan M, Tortolero-Luna G, Follen M, Tucker RA, Unger ER. Human papillomavirus type 16 E2 and E6/E7 variants. Gynecol Oncol 2005;96:695-700.  (pdf)

  • Shuhatovich OM, Sharman MP, Mirabal YN, Earle NR, Follen M, Basen-Engquist K. Participant recruitment and motivation for participation in optical technology for cervical cancer screening research trials. Gynecol Oncol 2005;99:S226-31.  (pdf)

  • Scheurer ME, Tortolero-Luna G, Guillaud M, Follen M, Chen Z, Dillon LM, Adler-Storthz K. Correlation of human papillomavirus type 16 and human papillomavirus type 18 e7 messenger RNA levels with degree of cervical dysplasia. Cancer Epidemiol Biomarkers Prev 2005;14:1948-52.  (pdf)

  • Sarkar AK, Tortolero-Luna G, Follen M, Sastry KJ. Inverse correlation of cellular immune responses specific to synthetic peptides from the E6 and E7 oncoproteins of HPV-16 with recurrence of cervical intraepithelial neoplasia in a cross-sectional study. Gynecol Oncol 2005;99:S251-61.  (pdf)

  • Pruitt SL, Parker PA, Peterson SK, Le T, Follen M, Basen-Engquist K. Knowledge of cervical dysplasia and human papillomavirus among women seen in a colposcopy clinic. Gynecol Oncol 2005;99:S236-44.  (pdf)

  • Park SY, Collier T, Aaron J, Markey M, Richards-Kortum R, Sokolov K, Mackinnon N, Macaulay C, Coghlan L, Milbourne A, Follen M. Multispectral digital microscopy for in vivo monitoring of oral neoplasia in the hamster cheek pouch model of carcinogenesis. Opt Express 2005;13:749-62.  (pdf)

  • Nida DL, Rahman MS, Carlson KD, Richards-Kortum R, Follen M. Fluorescent nanocrystals for use in early cervical cancer detection. Gynecol Oncol 2005;99:S89-94.  (pdf)

  • Milbourne A, Park SY, Benedet JL, Miller D, Ehlen T, Rhodes H, Malpica A, Matisic J, Van Niekirk D, Atkinson EN, Hadad N, Mackinnon N, Macaulay C, Richards-Kortum R, Follen M. Results of a pilot study of multispectral digital colposcopy for the in vivo detection of cervical intraepithelial neoplasia. Gynecol Oncol 2005;99:S67-75.  (pdf)

  • Marin NM, Milbourne A, Rhodes H, Ehlen T, Miller D, Benedet L, Richards-Kortum R, Follen M. Diffuse reflectance patterns in cervical spectroscopy. Gynecol Oncol 2005;99:S116-20.  (pdf)

  • Malpica A, Matisic JP, Niekirk DV, Crum CP, Staerkel GA, Yamal JM, Guillaud MH, Cox DD, Atkinson EN, Adler-Storthz K, Poulin NM, Macaulay CA, Follen M. Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issues. Gynecol Oncol 2005;99:S38-52.  (pdf)

  • Lee JS, Shuhatovich O, Price R, Pikkula B, Follen M, McKinnon N, Macaulay C, Knight B, Richards-Kortum R, Cox DD. Design and preliminary analysis of a study to assess intra-device and inter-device variability of fluorescence spectroscopy instruments for detecting cervical neoplasia. Gynecol Oncol 2005;99:S98-111.  (pdf)

  • Kim HG, Yamal JM, Xu XC, Hu W, Boiko I, Linares A, Vlastos AT, Atkinson EN, Malpica A, Hittelman WN, Follen M. Cervical chromosome 9 polysomy: validation and use as a surrogate endpoint biomarker in a 4-HPR chemoprevention trial. Gynecol Oncol 2005;99:S32-7.  (pdf)

  • Kamalov R, Guillaud M, Haskins D, Harrison A, Kemp R, Chiu D, Follen M, MacAulay C. A Java application for tissue section image analysis. Comput Methods Programs Biomed 2005;77:99-113.  (pdf)

  • Ho V, Yamal JM, Atkinson EN, Basen-Engquist K, Tortolero-Luna G, Follen M. Predictors of breast and cervical screening in Vietnamese women in Harris County, Houston, Texas. Cancer Nurs 2005;28:119-29; quiz 30-1.  (pdf)

  • Hamada K, Ueda N, Ito M, Roth JA, Follen M. The nude rat as an orthotopic model for cervical cancer. Gynecol Oncol 2005;99:S159-65.  (pdf)

  • Hamada K, Sakaue M, Sarkar A, Buchl S, Satterfield W, Keeling M, Sastry J, Roth JA, Follen M. Immune responses to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide. Gynecol Oncol 2005;99:S177-86.  (pdf)

  • Guillaud M, Adler-Storthz K, Malpica A, Staerkel G, Matisic J, Van Niekirk D, Cox D, Poulin N, Follen M, Macaulay C. Subvisual chromatin changes in cervical epithelium measured by texture image analysis and correlated with HPV. Gynecol Oncol 2005;99:S16-23.  (pdf)

  • Follen M, Crain S, MacAulay C, Basen-Engquist K, Cantor SB, Cox D, Atkinson EN, MacKinnon N, Guillaud M, Richards-Kortum R. Optical technologies for cervical neoplasia: update of an NCI program project grant. Clin Adv Hematol Oncol 2005;3:41-53.

  • Collier T, Follen M, Malpica A, Richards-Kortum R. Sources of scattering in cervical tissue: determination of the scattering coefficient by confocal microscopy. Appl Opt 2005;44:2072-81.  (pdf)

  • Chang SK, Pavlova I, Marin NM, Follen M, Richards-Kortum R. Fluorescence spectroscopy as a diagnostic tool for detecting cervical pre-cancer. Gynecol Oncol 2005;99:S61-3.  (pdf)

  • Chang SK, Mirabal YN, Atkinson EN, Cox D, Malpica A, Follen M, Richards-Kortum R. Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer. J Biomed Opt 2005;10:024031.  (pdf)

  • Carlson K, Pavlova I, Collier T, Descour M, Follen M, Richards-Kortum R. Confocal microscopy: imaging cervical precancerous lesions. Gynecol Oncol 2005;99:S84-8.  (pdf)

  • Carlson K, Chidley M, Sung KB, Descour M, Gillenwater A, Follen M, Richards-Kortum R. In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens. Appl Opt 2005;44:1792-7.  (pdf)

  • Cardenas-Turanzas M, Follen M, Benedet JL, Cantor SB. See-and-treat strategy for diagnosis and management of cervical squamous intraepithelial lesions. Lancet Oncol 2005;6:43-50.  (pdf)

  • Cantor SB, Atkinson EN, Cardenas-Turanzas M, Benedet JL, Follen M, MacAulay C. Natural history of cervical intraepithelial neoplasia: a meta-analysis. Acta Cytol 2005;49:405-15.

  • Bierl C, Karem K, Poon AC, Swan D, Tortolero-Luna G, Follen M, Wideroff L, Unger ER, Reeves WC. Correlates of cervical mucosal antibodies to human papillomavirus 16: results from a case control study. Gynecol Oncol 2005;99:S262-8.  (pdf)

  • Atkinson EN, Follen M. Interactive dynamic graphical techniques for the exploration of functional data. Gynecol Oncol 2005;99:S76-83.  (pdf)

  • Arifler D, Schwarz RA, Chang SK, Richards-Kortum R. Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and stroma. Appl Opt 2005;44:4291-4305.  (pdf)

  • Adewole IF, Benedet JL, Crain BT, Follen M. Evolving a strategic approach to cervical cancer control in Africa. Gynecol Oncol 2005;99:S209-12.  (pdf)
2005
2006
  • Swartz RJ, Cox DD, Cantor SB, Davies K, Follen M. Inverse decision theory: characterizing losses for a decision rule with applications in cervical cancer screening. J Am Stat Assoc 2006; 101:1-8.  (pdf)

  • Marin NM, MacKinnon N, MacAulay C, Chang SK, Atkinson EN, Cox D, Serachitopol D, Pikkula B, Follen M, Richards-Kortum R. Calibration standards for multicenter clinical trials of fluorescence spectroscopy for in vivo diagnosis. J Biomed Opt 2006;11:014010.  (pdf)

  • Lee BN, Follen M, Rodriquez G, Shen DY, Malpica A, Shearer WT, Reuben JM. Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer 2006;107:999-1007.  (pdf)

  • Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ, Szabo E, Jordan VC, Spitz MR, Mills GB, Papadimitrakopoulou VA, Lotan R, Aggarwal BB, Bresalier RS, Kim J, Arun B, Lu KH, Thomas ME, Rhodes HE, Brewer MA, Follen M, Shin DM, Parnes HL, Siegfried JM, Evans AA, Blot WJ, Chow WH, Blount PL, Maley CC, Wang KK, Lam S, Lee JJ, Dubinett SM, Engstrom PF, Meyskens FL, Jr., O'Shaughnessy J, Hawk ET, Levin B, Nelson WG, Hong WK. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res 2006;12:3661-97.    (pdf)

  • Hamada K, Shirakawa T, Gotoh A, Roth JA, Follen M. Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer. Gynecol Oncol 2006;103:820-30.  (pdf)

  • Guillaud M, Benedet JL, Cantor SB, Staerkel G, Follen M, MacAulay C. DNA ploidy compared with human papilloma virus testing (Hybrid Capture II) and conventional cervical cytology as a primary screening test for cervical high-grade lesions and cancer in 1555 patients with biopsy confirmation. Cancer 2006;107:309-18.  (pdf)

  • Chang SK, Marin N, Follen M, Richards-Kortum R. Model-based analysis of clinical fluorescence spectroscopy for in vivo detection of cervical intraepithelial dysplasia. J Biomed Opt 2006;11:024008.  (pdf)

  • Cantor SB, Levy LB, Cardenas-Turanzas M, Basen-Engquist K, Le T, Beck JR, Follen M. Collecting direct non-health care and time cost data: application to screening and diagnosis of cervical cancer. Med Decis Making 2006;26:265-72.  (pdf)

  • Arifler D, MacAulay C, Follen M, Richards-Kortum R. Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements. J Biomed Opt 2006;11:064027.  (pdf)